A study of multinucleated giant cells in esophageal cancer

To evaluate the occurrence, abundance, distribution, nature and clinical significance of multinucleated giant cell (MGC) in esophageal cancer. MGCs were examined with conventional pathology, immunohistochemistry immunofluorescence 107 cancer tissues. The findings correlated to pathological diagnosis behavior cancers. identified 31.7% (34/107) cases. positive for CD11c, CD11b, CD32, CD16, HLA-DR MMP9, negative CD163, CD206 CD64 giving a molecular profile proinflammatory M1 but not immunosuppressive M2. significantly related decreased lymph node metastasis (p = 0.011), low pTNM stage 0.044), favorable survival 0.04), squamous type rather than other histopathological subtypes 0.020) associated better differentiation 0.063). belong macrophage perform phagocytosis scavenging cells that would benefit patients' could serve as prognostic marker.